A framework for enabling a user equipment (UE) to apply interference suppression processing during network conditions that are favorable to interference suppression or that are known is provided. The framework includes an interference suppression (IS) time and frequency (time/frequency) zone, which can be scheduled by a serving base station and signaled to the UE. In an embodiment, the serving base station coordinates with the interfering base station(s) to create a network condition favorable to interference suppression at the UE during the IS time/frequency zone. In another embodiment, the serving base station opportunistically schedules the IS time/frequency zone for the UE whenever it determines favorable transmission parameters being used or scheduled for use by the interfering base station(s). The UE applies interference suppression processing within the IS time/frequency zone, thereby improving receiver performance. Outside the time/frequency zone, the UE may disable interference suppression processing so as not to degrade receiver performance.