Invention Grant
US09464082B2 Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
有权
芳基和芳基烷基取代的吡唑基和嘧啶基三环烯酮作为抗氧化剂炎症调节剂
- Patent Title: Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
- Patent Title (中): 芳基和芳基烷基取代的吡唑基和嘧啶基三环烯酮作为抗氧化剂炎症调节剂
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Application No.: US14604129Application Date: 2015-01-23
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Publication No.: US09464082B2Publication Date: 2016-10-11
- Inventor: Pamela Donner , Rolf Wagner , Jason Shanley , Howard Heyman , Allan Krueger , Hui-Ju Chen , Michael Rozema , David Grampovnik , Melean Visnick , Eric Anderson , Xin Jiang , Christopher F. Bender , Gary Louis Bolton , Bradley William Caprathe , Chitase Lee , William Howard Roark
- Applicant: AbbVie Inc. , Reata Pharmaceuticals, Inc.
- Applicant Address: US IL North Chicago US TX Irving
- Assignee: AbbVie Inc.,Reata Pharmaceuticals, Inc.
- Current Assignee: AbbVie Inc.,Reata Pharmaceuticals, Inc.
- Current Assignee Address: US IL North Chicago US TX Irving
- Main IPC: C07D231/54
- IPC: C07D231/54 ; C07D239/70 ; C07D239/72 ; C07D401/04 ; C07D403/04 ; C07D417/04 ; C07D471/04 ; C07D413/04
Abstract:
The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
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