Invention Grant
- Patent Title: Substituted triazole boronic acid compounds
- Patent Title (中): 取代的三唑硼酸化合物
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Application No.: US14646782Application Date: 2013-11-29
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Publication No.: US09464098B2Publication Date: 2016-10-11
- Inventor: Stephen M. Lynch , Werner Neidhart , Jean-Marc Plancher , Tanja Schulz-Gasch
- Applicant: Hoffmann-La Roche Inc. , F. HOFFMANN-LA ROCHE AG
- Applicant Address: US NJ Nutley
- Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee Address: US NJ Nutley
- International Application: PCT/EP2013/075031 WO 20131129
- International Announcement: WO2014/086664 WO 20140612
- Main IPC: A61K31/4192
- IPC: A61K31/4192 ; C07F5/02

Abstract:
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.
Public/Granted literature
- US20150329565A1 SUBSTITUTED TRIAZOLE BORONIC ACID COMPOUNDS Public/Granted day:2015-11-19
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