A safety rail system in some embodiments may include integrated ergonomic hand-grip projections, and structures for affixing the system for egress and ingress through an opening, such as roof or floor access holes. A self-closing gravity gate may be provided acting as additional hand-grip, support, and barrier. The safety rail system may be constructed and assembled using a unique continuous tubular structure of converging vertical and angular upright post with horizontal upper rail, forward protruding ergonomically effecting hand-grip and opposing directionally horizontal lower attachment support means reducing lateral motion and allows installation for new construction or retro fitting of existing openings.