Systems and methods for generating and storing a data structure for maintaining cache supporting compression and cache-wide deduplication, including generating data structures with fixed size memory regions configured to hold multiple signatures as keys, wherein the number of the fixed size memory regions is bounded. A first mapping is generated from short-length signatures to a storage location and a quantized length measure on a cache storage device; and unused contiguous regions on the cache device are allocated. Metadata and cache page content is retrieved using a single input/output operation; a correctness of a full value of hash functions of uncompressed cache page content is validated; a second mapping is generated from short-length signatures to entries in the first mapping; and verification of whether the cached page content corresponds to a full-length original logical block address using the metadata is performed.