A control circuit, control method used in a PFC circuit and the power source system thereof are disclosed herein. The control circuit comprises: a zero current detection circuit having a polarity detection circuit for outputting a first and a second digital signals and a signal conversion circuit for generating an analog signal; a feedback circuit for generating a driving pulse signal; and a pulse distribution circuit for distributing the driving pulse signal to a first and a second switches according to the first and the second digital signal. After a switch cycle, one of the first and the second switch performs an ON operation for the next switch cycle when the current flowing through the inductor decreases to a predetermined threshold value, wherein an ON time of the first switch is equal in each switch cycle, and an ON time of the second switch is equal in each switch cycle.