Approaches for multilayer pattern transfer for chemical guides are provided. In a typical embodiment, a device is formed by forming an etch mask layer (e.g., a nitride layer and an oxide layer) over a substrate (e.g., silicon (Si)). An orientation control layer (e.g., a neutral layer) is then formed over the etch mask layer, and an ARC layer (e.g., SiARC) is formed over the orientation control layer. In other embodiments, an organic planarization layer (OPL) and/or a protection layer may also be formed between the ARC layer and the orientation control layer. Regardless, a tapered etch profile/pattern may then be formed through the ARC and/or other layers.