发明授权
US09482669B2 Crystal structure of the NanR and ManNAc-6P complex, and uses thereof
有权
NanR和ManNAc-6P复合物的晶体结构及其用途
- 专利标题： Crystal structure of the NanR and ManNAc-6P complex, and uses thereof
- 专利标题（中）： NanR和ManNAc-6P复合物的晶体结构及其用途
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申请号： US14310879申请日： 2014-06-20
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公开(公告)号： US09482669B2公开(公告)日： 2016-11-01
- 发明人: Sang Ho Choi , Byoung Sik Kim , Myung Hee Kim , Jung Won Hwang
- 申请人： SNU R&DB FOUNDATION , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 申请人地址： KR Seoul KR Daejeon
- 专利权人： SNU R&DB FOUNDATION,KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人： SNU R&DB FOUNDATION,KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人地址： KR Seoul KR Daejeon
- 代理机构： Gavrilovich, Dodd & Lindsey LLP
- 代理商 Joseph R. Baker, Jr
- 优先权： KR10-2013-0071369 20130621
- 主分类号： G01N33/569
- IPC分类号： G01N33/569 ; C07K14/28
摘要：
The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of NanR which is a key pathogenic regulatory protein of Vibrio vulnificus and ManNA6P which is a NanR regulator. Further, the present invention relates to a modified NanR protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector. Furthermore, the present invention relates to a method for screening a substance regulating interaction between NanR and the transcriptional control region of nan operon which is a gene cluster regulated by NanR, or a substance regulating interaction between NanR and ManNAc-6P, by designing three-dimensional structure of the complex, and to an antibacterial composition including the screened substance.