System and method enabling multiple users to simultaneously share a client computing device are disclosed. Method includes retrieving a plurality of I/O device groups, wherein a first I/O device group in the plurality of I/O device groups is associated with a first group of input or output (IO) devices locally connected to a client computing device, and wherein a second I/O device group in the plurality of I/O device groups is associated with a second group of I/O devices locally connected to the client computing device. Method includes launching first and second instances of an application. Method includes associating the first instance of the application with the first I/O device group on the client computing device. Method includes associating the second instance of the application associated with the second I/O device group on the client computing device.