A method and apparatus are provided for transmitting symbols in wireless communication system. A method includes determining a channel quality indicator (CQI) and one or more acknowledgements; generating a first symbol based on the CQI; generating a second symbol based on the one or more acknowledgements; and transmitting the first symbol and the second symbol in a slot. One of a first code and a second code is applied for generating the second symbol, if the one or more acknowledgements is one bit. One of the first code, the second code, a third code, and a fourth code is applied for generating the second symbol, if the one or more acknowledgements are two bits.