Invention Grant
- Patent Title: Method for producing sulfonyl chloride compound
- Patent Title (中): 磺酰氯化合物的制备方法
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Application No.: US14770914Application Date: 2014-02-27
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Publication No.: US09487485B2Publication Date: 2016-11-08
- Inventor: Keisuke Majima
- Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Applicant Address: JP Osaka
- Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee Address: JP Osaka
- Agency: Nath, Goldberg & Meyer
- Agent Joshua B. Goldberg; Scott H. Blackman
- Priority: JP2013-039809 20130228
- International Application: PCT/JP2014/054808 WO 20140227
- International Announcement: WO2014/133059 WO 20140904
- Main IPC: C07D213/71
- IPC: C07D213/71 ; C07D401/12

Abstract:
An object of the present invention is to provide a production method of an intermediate used in the production method of a sulfonylpyrrole compound useful as a pharmaceutical product. The present invention relates to a method of producing sulfonylpyrrole compound (VI) by reacting a pyridine-3-sulfonic acid compound with phosphorus pentachloride in a solvent of chlorobenzene or trifluoromethylbenzene to give a pyridine-3-sulfonyl chloride compound, reacting the compound without isolation with compound (III) to give compound (IV), and subjecting the compound (IV) to a reductive amination reaction. wherein R2 is a hydrocarbon group etc. and R3 and R4 are each a hydrogen atom etc., wherein R1 is an optionally substituted pyridin-3-yl group, and the other symbols are as defined above, wherein R5 is an alkyl group and the other symbols are as defined above.
Public/Granted literature
- US20160009646A1 METHOD FOR PRODUCING SULFONYL CHLORIDE COMPOUND Public/Granted day:2016-01-14
Information query
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