发明授权
US09487533B2 Phosphoinositide 3-kinase inhibitor compounds and methods of use
有权
磷酸肌醇3-激酶抑制剂化合物及其使用方法
- 专利标题: Phosphoinositide 3-kinase inhibitor compounds and methods of use
- 专利标题(中): 磷酸肌醇3-激酶抑制剂化合物及其使用方法
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申请号: US11951189申请日: 2007-12-05
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公开(公告)号: US09487533B2公开(公告)日: 2016-11-08
- 发明人: Georgette Castanedo , Jennafer Dotson , Richard Goldsmith , Janet Gunzner , Tim Heffron , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Steven Staben , Vickie Tsui , Tracy Bayliss , Irina Chuckowree , Adrian Folkes , Nan Chi Wan
- 申请人: Georgette Castanedo , Jennafer Dotson , Richard Goldsmith , Janet Gunzner , Tim Heffron , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Steven Staben , Vickie Tsui , Tracy Bayliss , Irina Chuckowree , Adrian Folkes , Nan Chi Wan
- 申请人地址: US CA South San Francisco CH Basel
- 专利权人: Genentech, Inc.,F. Hoffmann-La Roche AG
- 当前专利权人: Genentech, Inc.,F. Hoffmann-La Roche AG
- 当前专利权人地址: US CA South San Francisco CH Basel
- 代理机构: Viksnins Harris & Padys PLLP
- 主分类号: C07D491/048
- IPC分类号: C07D491/048 ; C07D495/04
摘要:
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.