The present invention discloses an optical touch panel system, an optical sensing module, and an operation method using for the same system. The system recognizes a track of an object moving on or above a touch control surface to determine a corresponding gesture function; it includes a touch control surface, at least one image sensor, and a processor. The touch control surface includes at least two touch control areas. The image sensor captures a plurality of continuous pictures including the images of the objects. The processer determines which touch control area the object is moving on or above according to a starting position or a path of the track, and executes a gesture function corresponding to the track and the touch control area.