The present disclosure is directed to systems and methods for performing single sign on by an intermediary device for a remote desktop session of a client. A first device intermediary to a plurality of clients and a plurality of servers authenticates a user and establishes a connection to the user's client device. The device provides a homepage including links to one or more remote desktop hosts associated with the user. The device receives a request to launch an RDP session with a remote desktop host via the homepage and generates RDP content, including a security token, for the user. The device receives a second request that includes the security token to launch the RDP session. The device validates the user using the security token and establishes a connection to the remote desktop host. The device signs into the desktop host using session credentials.