发明授权
- 专利标题: Insulin conjugate using an immunoglobulin fragment
- 专利标题(中): 使用免疫球蛋白片段的胰岛素缀合物
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申请号: US13638786申请日: 2011-04-04
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公开(公告)号: US09492507B2公开(公告)日: 2016-11-15
- 发明人: Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
- 申请人: Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
- 申请人地址: KR Hwaseong-si
- 专利权人: HANMI SCIENCE CO., LTD.
- 当前专利权人: HANMI SCIENCE CO., LTD.
- 当前专利权人地址: KR Hwaseong-si
- 代理机构: Sughrue Mion, PLLC
- 优先权: KR10-2010-0030575 20100402
- 国际申请: PCT/KR2011/002331 WO 20110404
- 国际公布: WO2011/122921 WO 20111006
- 主分类号: C07K14/62
- IPC分类号: C07K14/62 ; A61K38/28 ; A61K47/48
摘要:
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
公开/授权文献
- US20130028918A1 INSULIN CONJUGATE USING AN IMMUNOGLOBULIN FRAGMENT 公开/授权日:2013-01-31