发明授权
- 专利标题： Optically active PDE10 inhibitor
- 专利标题（中）： 光学活性PDE10抑制剂
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申请号： US14696295申请日： 2015-04-24
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公开(公告)号： US09493447B2公开(公告)日： 2016-11-15
- 发明人: Neil S. Cutshall , Kenneth M. Ferguson , Charles Prince Zuta
- 申请人： OMEROS CORPORATION
- 申请人地址： US WA Seattle
- 专利权人： Omeros Corporation
- 当前专利权人： Omeros Corporation
- 当前专利权人地址： US WA Seattle
- 代理机构： Seed IP Law Group LLP
- 主分类号： C07D417/10
- IPC分类号： C07D417/10
摘要：
The present invention is directed to a pure enantiomer of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, in particular, (S)-1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone. The present invention is also directed a crystal structure of (S)-1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, a pharmaceutical composition of (S)-1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, a method of inhibiting PDE10 with (S)-1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, and a process and particular individual intermediates used in the production of (S)-1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone.
公开/授权文献
- US20160024070A1 OPTICALLY ACTIVE PDE10 INHIBITOR 公开/授权日：2016-01-28
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