发明授权
US09493833B1 Methods for preventing induced synthesis of proteasomes in human cells
有权
用于预防人细胞中蛋白酶体诱导合成的方法
- 专利标题： Methods for preventing induced synthesis of proteasomes in human cells
- 专利标题（中）： 用于预防人细胞中蛋白酶体诱导合成的方法
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申请号： US12941959申请日： 2010-11-08
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公开(公告)号： US09493833B1公开(公告)日： 2016-11-15
- 发明人: Raymond J. Deshaies , Senthil Radhakrishnan , Candy S. Lee , Jefferson Y. Chan
- 申请人： Raymond J. Deshaies , Senthil Radhakrishnan , Candy S. Lee , Jefferson Y. Chan
- 申请人地址： US CA Oakland US CA Pasadena
- 专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： US CA Oakland US CA Pasadena
- 代理机构： Lewis Roca Rothgerber Christie LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/574 ; A61K48/00 ; A61K38/00
摘要：
Methods and compositions for inhibiting Nrf1 activity are provided for enhancing apoptosis in mammalian cells. Apoptosis is enhanced in mammalian cells by co-inhibiting Nrf1 activity and proteasome activity. Methods for identifying Nrf1 inhibitors are provided using an assay for screening Nrf1 inhibitors that enhance proteasome inhibition by preventing induced proteasome expression.
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