- 专利标题： Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same
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申请号： US13873543申请日： 2013-04-30
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公开(公告)号： US09493845B2公开(公告)日： 2016-11-15
- 发明人: Liangxian Cao , Panayiota Trifillis
- 申请人： PTC Therapeutics, Inc.
- 申请人地址： US NJ South Plainfield
- 专利权人： PTC THERAPEUTICS, INC.
- 当前专利权人： PTC THERAPEUTICS, INC.
- 当前专利权人地址： US NJ South Plainfield
- 代理机构： Jones Day
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07K14/52 ; G01N33/50
摘要：
The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
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