发明授权
US09497943B2 Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides
有权
编码通过自切割肽连接的重编程因子的核酸构建体
- 专利标题： Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides
- 专利标题（中）： 编码通过自切割肽连接的重编程因子的核酸构建体
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申请号： US12997815申请日： 2009-06-15
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公开(公告)号： US09497943B2公开(公告)日： 2016-11-22
- 发明人: Rudolf Jaenisch , Bryce Woodbury Carey
- 申请人： Rudolf Jaenisch , Bryce Woodbury Carey
- 申请人地址： US MA Cambridge
- 专利权人： Whitehead Institute for Biomedical Research
- 当前专利权人： Whitehead Institute for Biomedical Research
- 当前专利权人地址： US MA Cambridge
- 代理机构： Morse, Barnes-Brown & Pendleton P.C.
- 代理商 Lisa M. Warren, Esq.
- 国际申请： PCT/US2009/047423 WO 20090615
- 国际公布： WO2009/152529 WO 20091217
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; A01K67/027 ; C12N5/074 ; G01N33/50 ; C12N15/86 ; C12N15/85 ; C12N5/0735 ; C12N15/79
摘要：
The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
公开/授权文献
- US20120028821A1 PROGRAMMING AND REPROGRAMMING OF CELLS 公开/授权日：2012-02-02