Invention Grant
US09505748B2 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFNα responses
有权
酰胺取代的杂环化合物可用作IL-12，IL-23和/或IFNα应答的调节剂
- Patent Title: Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFNα responses
- Patent Title (中): 酰胺取代的杂环化合物可用作IL-12，IL-23和/或IFNα应答的调节剂
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Application No.: US14441183Application Date: 2013-11-07
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Publication No.: US09505748B2Publication Date: 2016-11-29
- Inventor: Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Shuqun Lin , Steven H. Spergel , Yanlei Zhang
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- International Application: PCT/US2013/068846 WO 20131107
- International Announcement: WO2014/074661 WO 20140515
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D417/14 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D237/24 ; C07D413/12 ; C07D413/14
Abstract:
Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.
Public/Granted literature
- US20150299183A1 AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES Public/Granted day:2015-10-22
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