Invention Grant
US09505767B2 Pyrazolo[1,5-A]pyrimidin-7(4H)-onehistone demethylase inhibitors
有权
吡唑并[1,5-a]嘧啶-7（4H） - 酮组成脱甲基酶抑制剂
![Pyrazolo[1,5-A]pyrimidin-7(4H)-onehistone demethylase inhibitors](/docs/US/2016-11-29/US09505767B2/abs.jpg.600x600.jpg)
- Patent Title: Pyrazolo[1,5-A]pyrimidin-7(4H)-onehistone demethylase inhibitors
- Patent Title (中): 吡唑并[1,5-a]嘧啶-7（4H） - 酮组成脱甲基酶抑制剂
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Application No.: US14477566Application Date: 2014-09-04
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Publication No.: US09505767B2Publication Date: 2016-11-29
- Inventor: Brian K. Albrecht , Steven F. Bellon , Victor S. Gehling , Jean-Christophe Harmange , Yves LeBlanc , Jun Liang , Steven R. Magnuson , Vickie Hsiao-Wei Tsui , Birong Zhang
- Applicant: Genentech, Inc. , Constellation Pharmaceuticals, Inc.
- Applicant Address: US CA South San Francisco US MA Cambridge
- Assignee: Genentech, Inc.,Constellation Pharmaceuticals, Inc.
- Current Assignee: Genentech, Inc.,Constellation Pharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco US MA Cambridge
- Agency: Viksnins Harris & Padys PLLP
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61K45/06 ; A61N5/10
![Pyrazolo[1,5-A]pyrimidin-7(4H)-onehistone demethylase inhibitors](/abs-image/US/2016/11/29/US09505767B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Public/Granted literature
- US20150065522A1 THERAPEUTIC COMPOUNDS AND USES THEREOF Public/Granted day:2015-03-05
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