- 专利标题： Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
-
申请号： US14773686申请日： 2014-03-10
-
公开(公告)号： US09505781B2公开(公告)日： 2016-11-29
- 发明人: Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jay Hess , Duxin Sun , Xiaoqin Li
- 申请人： The Regents of the University of Michigan
- 申请人地址： US MI Ann Arbor
- 专利权人： The Regents of the University of Michigan
- 当前专利权人： The Regents of the University of Michigan
- 当前专利权人地址： US MI Ann Arbor
- 代理机构： Casimir Jones SC
- 代理商 David W. Staple
- 国际申请： PCT/US2014/022750 WO 20140310
- 国际公布： WO2014/164543 WO 20141009
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07D519/00 ; C07D495/16
摘要：
The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 4b: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.
公开/授权文献
信息查询
