发明授权
US09505809B2 Proteins with repetitive bacterial-IG-like (BIG) domains present in Leptospira species
有权
存在于钩端螺旋体属中的重复细菌IG样（BIG）结构域的蛋白质
- 专利标题： Proteins with repetitive bacterial-IG-like (BIG) domains present in Leptospira species
- 专利标题（中）： 存在于钩端螺旋体属中的重复细菌IG样（BIG）结构域的蛋白质
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申请号： US15134168申请日： 2016-04-20
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公开(公告)号： US09505809B2公开(公告)日： 2016-11-29
- 发明人: Albert I. Ko , Mitermayer Galvão Reis , Julio Henrique Rosa Croda , Isadora Cristina Siqueira , David A. Haake , James Matsunaga , Lee W. Riley , Michele Barocchi , Tracy Ann Young
- 申请人： The United States of America represented by the Department of Veterans Affairs , The Regents of the University of California , Cornell Research Foundation, Inc. , Fundação Oswaldo Cruz
- 申请人地址： US NY Ithaca US CA Oakland US DC Washington BR Rio de Janeiro
- 专利权人： Cornell Research Foundation, Inc.,The Regents of the University of California,The United States of America as represented by the Department of Veterans Affairs,Fundação Oswaldo Cruz—FIOCRUZ
- 当前专利权人： Cornell Research Foundation, Inc.,The Regents of the University of California,The United States of America as represented by the Department of Veterans Affairs,Fundação Oswaldo Cruz—FIOCRUZ
- 当前专利权人地址： US NY Ithaca US CA Oakland US DC Washington BR Rio de Janeiro
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07K14/20
摘要：
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.