The present invention provides a pixel driving circuit and a driving method thereof, and a display device. The pixel driving circuit is used for driving a pixel array, wherein each pixel in the pixel array comprises four sub-pixels with different colors, and wherein the pixel driving circuit comprises: at least one first sub-pixel driving chip and at least one second sub-pixel driving chip, wherein the at least one first sub-pixel driving chip each is connected to a part of sub-pixels corresponding thereto in corresponding pixels to drive them, and the at least one second sub-pixel driving chip each is connected to the other part of sub-pixels corresponding thereto in the corresponding pixels to drive them. In the invention, noise interference can be avoided, and the display quality is improved; the cost is reduced; signal transmitting efficiency is increased and the EMI characteristic of products is improved.