The present invention provides a driving method of a pixel array, wherein the driving method includes: step 1, obtaining a theoretical brightness value of each sub-pixel for an image to be displayed; step 2, calculating an actual brightness value of each sub-pixel, the actual brightness value of a sub-pixel to be calculated is a sum of a part of the theoretical brightness value of the sub-pixel to be calculated and a part of the theoretical brightness values of a plurality of auxiliary sub-pixels corresponding to the sub-pixel to be calculated; and step 3, outputting a signal to each sub-pixel so that the brightness value of each sub-pixel reaches the actual brightness value thereof which is obtained in the step 2. The present invention further provides a driving module of a pixel array and a display device.