Conditional predictive multi-symbol run-length coding may include generating a differential residual block based on a residual block and a reconstructed residual block, entropy encoding the differential residual block by determining a symbol order for a plurality of symbols in the differential residual block, grouping the plurality of symbols into at least a first group and a second group based on the symbol order, run-length encoding the plurality of symbols in the differential residual block, by on a condition that a first symbol from the plurality of symbols is associated with the first group, encoding a second symbol from the plurality of symbols, and on a condition that the first symbol is associated with the second group, modifying the second symbol and encoding the modified second symbol.