A system includes a nitrogen oxide reduction catalyst fluidly coupled to an exhaust conduit of an engine system. The nitrogen oxide reduction catalyst is configured to reduce nitrogen oxides in an engine exhaust. The system also includes an ammonia oxidation catalyst fluidly coupled to the exhaust conduit downstream of the nitrogen oxide reduction catalyst and configured to reduce ammonia in the engine exhaust. Further, the system includes a reductant injection control system configured to control an injection of reductant into the exhaust conduit, determine a first nitrogen oxide conversion rate of the nitrogen oxide reduction catalyst, determine an ammonia storage value of the nitrogen oxide reduction catalyst, and determine a first temperature of the engine exhaust upstream of the ammonia oxidation catalyst. The reductant injection control system is also configured to increase or decrease the injection of reductant based on the first nitrogen oxide conversion, the ammonia storage value, and the first temperature.