发明授权
US09518259B2 Compounds and methods for modulating interaction between proteins and target nucleic acids
有权
用于调节蛋白质和靶核酸之间相互作用的化合物和方法
- 专利标题： Compounds and methods for modulating interaction between proteins and target nucleic acids
- 专利标题（中）： 用于调节蛋白质和靶核酸之间相互作用的化合物和方法
-
申请号： US13703322申请日： 2011-06-15
-
公开(公告)号： US09518259B2公开(公告)日： 2016-12-13
- 发明人: Frank Rigo , C. Frank Bennett , Adrian R. Krainer , Yimin Hua
- 申请人： Frank Rigo , C. Frank Bennett , Adrian R. Krainer , Yimin Hua
- 申请人地址： US CA Carlsbad
- 专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Ionis Pharmaceuticals, Inc. Patent Dept.
- 国际申请： PCT/US2011/040581 WO 20110615
- 国际公布： WO2011/159836 WO 20111222
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; A61K48/00 ; C12Q1/68 ; C12N15/113 ; C07H21/04
摘要：
Provided herein are antisense compounds and methods for recruiting one or more non-cleaving protein to a target nucleic acid in a cell. In certain instances such recruitment of a non-cleaving protein alters the function or activity of the target nucleic acid. In certain such instances, the target nucleic acid a pre-mRNA and the recruitment of the non-cleaving protein results in a change in splicing of the pre-mRNA.
公开/授权文献
信息查询
IPC分类:
