The present invention is provided for a transmission device with air-float guide wheel to guide the liquid crystal display panel, which comprising an air-float supplying platform, two air-float guide groups and a magnetic wheel driving device, wherein a plurality of gas holes are opening on the air-float supplying platform, the two air-float guide groups are assembled at the two sides of the air-float supplying platform, the magnetic wheel is connected with the air-float guide groups, and the air-float guide groups can be rotating with the magnetic wheel rolling, the air can be flowing through the gas holes of the air-float supplying platform, the liquid crystal display panel can be limited and transmitted by the two air-float guide groups in the rolling direction.