The present disclosure relates generally to gaming systems and methods for providing a card game that employs multiple-sided playing cards. In various embodiments, the gaming system enables a player to play one or more games which utilize one or more sets or decks of multiple-sided playing cards or multiple-sided tiles. In such embodiments, a first side of each multiple-sided playing card is associated with one of a plurality of playing cards from a first set or deck of playing cards for a first game and a second side of each multiple-sided playing card is associated with one of a plurality of playing cards from a second, different set or deck of playing cards for a second, different game.