Embodiments of the present invention provide a multi-user interference suppression method, terminal and base station. The method includes performing layer mapping on and precoding service data of each of paired users to obtain precoded output data, mapping the precoded output data and a common pilot sequence to a port of an antenna array for sending to each user by using the antenna array. Correspondingly, the embodiments of the present invention further provide a data receiving method, base station and terminal. By using a common pilot sequence based on the paired users, the same pilot sequence is used for each user in the paired users of a cell or a collaborative area, which is different from the technical solution in the prior art where a user-specific pilot is used and pilots of different users are orthogonal.