Embodiments of the present invention provide a method and an apparatus for determining a coordinated multi-point transmission/reception CoMP coordination set, which can increase an interference suppression gain during CoMP. The method includes: receiving, by a first cell, CoMP resource block information of a second cell sent by the second cell, where the CoMP resource block information of the second cell indicates a CoMP resource block of the second cell; obtaining, by the first cell, a CoMP coordination set of each CoMP resource block of the first cell according to CoMP resource blocks of the first cell and the CoMP resource blocks of the second cell; and determining, by the first cell, that a union set of CoMP coordination sets of all the CoMP resource blocks of the first cell is a CoMP coordination set of the first cell.