The present invention provides a method and apparatus for transmitting uplink control information (UCI) with user equipment in a wireless communication system. The user equipment performs channel coding on information bits of UCI to generate encoded information bits; modulates the generated encoded information bits to generate complex modulation symbols; spreads the complex modulation symbols blockwise into a plurality of single carrier frequency division multiple access (SC-FDMA) symbols on the basis of an orthogonal sequence; and transmits the spread complex modulation symbols to a base station.