Invention Grant
US09539222B2 Methods to inhibit intracellular growth of bacteria and to treat bacteria-mediated diseases
有权
抑制细菌的细胞内生长和治疗细菌介导的疾病的方法
- Patent Title: Methods to inhibit intracellular growth of bacteria and to treat bacteria-mediated diseases
- Patent Title (中): 抑制细菌的细胞内生长和治疗细菌介导的疾病的方法
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Application No.: US14426659Application Date: 2013-09-04
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Publication No.: US09539222B2Publication Date: 2017-01-10
- Inventor: Amit Singhal , Gennaro De Libero
- Applicant: Agency for Science, Technology and Research
- Applicant Address: SG Singapore
- Assignee: Agency for Science, Technology and Research
- Current Assignee: Agency for Science, Technology and Research
- Current Assignee Address: SG Singapore
- Agency: Schwegman Lundberg & Woessner, P.A.
- Priority: SG201206669-2 20120907
- International Application: PCT/SG2013/000388 WO 20130904
- International Announcement: WO2014/039011 WO 20140313
- Main IPC: A61K31/155
- IPC: A61K31/155 ; A61K31/343 ; A61K45/06 ; A61K31/4422 ; A61K31/52 ; A61K31/05 ; A61K31/7076 ; A61K31/277 ; A61K31/40 ; A61K31/4409 ; A61K31/451 ; A61K31/675 ; A61K31/553 ; A61K31/4178 ; A61K31/421
Abstract:
Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof.
Public/Granted literature
- US20150209308A1 METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES Public/Granted day:2015-07-30
Information query
