Compression of an input signal prior to high power radio frequency (RF) amplification and transmission is disclosed. A compression device can receive an input signal and generate a compressed signal that can be passed to an amplification stage to reduce intermodulation effects. The compression device can further generate compression information that can be transmitted to enable a mobile device receiving an amplified version of the compressed signal and the compression information to decompress the amplified version of the compressed signal. Further, a mobile device that can receive an amplified compressed signal and compression information, such that the mobile device can decompress the amplified compressed signal, is also disclosed. The disclosed subject matter can enable use of lower cost, smaller, and less complex RF amplifiers within a wireless network environment.