The disclosure relates to an automatic gain adjustment and control method and device for eliminating the interference between the GSM and the LTE in the MSR receiver. The method comprises: in an MSP receiver, an upper threshold and a lower threshold which are used for starting up gain control function are set; the ADC power of an ADC of the MSP receiver is detected when LTE OFDM starts; the detected ADC power is compared with the upper threshold and the lower threshold respectively; and based on that the comparison result is that the ADC power is larger than the upper threshold or is smaller than the lower threshold, the gain control function of the MSP receiver is started up, and otherwise, the gain control function of the MSP receiver is not started up. The disclosure can control the LTE and GSM signal power within a certain range.