Invention Grant
US09546156B2 N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors
有权
N-双环芳基,N'-吡唑基脲,硫脲,胍氰腈化合物作为TrkA激酶抑制剂
- Patent Title: N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors
- Patent Title (中): N-双环芳基,N'-吡唑基脲,硫脲,胍氰腈化合物作为TrkA激酶抑制剂
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Application No.: US14442584Application Date: 2013-11-12
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Publication No.: US09546156B2Publication Date: 2017-01-17
- Inventor: Shelley Allen , James F. Blake , Barbara J. Brandhuber , Yutong Jiang , Gabrielle R. Kolakowski , Rui Xu , Shannon L. Winski
- Applicant: Array BioPharma Inc.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: Viksnins Harris & Padys PLLP
- Agent Sarah S. Mastous
- International Application: PCT/US2013/069747 WO 20131112
- International Announcement: WO2014/078328 WO 20140522
- Main IPC: C07D231/40
- IPC: C07D231/40 ; C07D231/52 ; C07D231/56 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D401/14

Abstract:
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
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