Invention Grant
- Patent Title: Synthetic lariat RNA for RNA interference
- Patent Title (中): RNA干扰RNA的合成
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Application No.: US14213164Application Date: 2014-03-14
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Publication No.: US09546364B2Publication Date: 2017-01-17
- Inventor: Subha Ranjan Das , Eduardo Paredes
- Applicant: Carnegie Mellon University
- Applicant Address: US PA Pittsburgh
- Assignee: Carnegie Mellon University
- Current Assignee: Carnegie Mellon University
- Current Assignee Address: US PA Pittsburgh
- Agency: The Webb Law Firm
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/11
Abstract:
Provided herein are compositions for the modification of gene expression by RNA interference using a microRNA (miRNA) guide strand precursor. Methods of making and using the miRNA guide strand precursor also are provided. The compositions bypass the Drosha-Exportin-Dicer pathway and are resistant to nucleases.
Public/Granted literature
- US20140273216A1 Synthetic Lariat RNA for RNA Interference Public/Granted day:2014-09-18
Information query
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