An example method for flexible remote direct memory access resource configuration in a network environment is provided and includes determining whether sufficient remote direct memory access (RDMA) resources are available in a network environment to satisfy a request for RDMA resources, inserting the requested RDMA resources into a network profile, associating the network profile with a network interface endpoint in the network, and communicating the network profile over the network to a virtual interface card (VIC) adapter that processes RDMA packets, the VIC adapter configuring the requested RDMA resources in the VIC adapter's hardware and the requested RDMA resources being mapped to a host memory for use by the network interface endpoint. In specific embodiments, the VIC adapter allocates and identifies a region in local memory for managing the requested RDMA resources and reserved for the network interface endpoint.