Invention Grant
US09550997B2 Screening of abundantly secreted proteins and their use as fusion partners for the production of recombinant proteins
有权
筛选大量分泌的蛋白质及其作为重组蛋白质生产的融合伙伴的用途
- Patent Title: Screening of abundantly secreted proteins and their use as fusion partners for the production of recombinant proteins
- Patent Title (中): 筛选大量分泌的蛋白质及其作为重组蛋白质生产的融合伙伴的用途
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Application No.: US12631449Application Date: 2009-12-04
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Publication No.: US09550997B2Publication Date: 2017-01-24
- Inventor: Jung-Hoon Sohn , Jung-Hoon Bae , Hyun-Jin Kim , Kwang-Mook Lim
- Applicant: Jung-Hoon Sohn , Jung-Hoon Bae , Hyun-Jin Kim , Kwang-Mook Lim
- Applicant Address: KR Daejeon
- Assignee: Korean Research Institute of Bioscience and Biotechnology
- Current Assignee: Korean Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12P21/02 ; C12N15/62
Abstract:
The present invention relates techniques for identifying suitable secretion fusion partner (SFP) for hyper-secretory production of recombinant proteins. The SFPs can be obtained from secretome analyzes. Recombinant proteins are produced in a fusion form with a secretion fusion partner (SFP) and can be separated from the SFP by in vitro protease treatment. SFPs of this invention greatly improve the secretion level of target proteins and peptides which are valuable for bio-pharmaceuticals and the bio-industry.
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