发明授权
US09550997B2 Screening of abundantly secreted proteins and their use as fusion partners for the production of recombinant proteins
有权
筛选大量分泌的蛋白质及其作为重组蛋白质生产的融合伙伴的用途
- 专利标题： Screening of abundantly secreted proteins and their use as fusion partners for the production of recombinant proteins
- 专利标题（中）： 筛选大量分泌的蛋白质及其作为重组蛋白质生产的融合伙伴的用途
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申请号： US12631449申请日： 2009-12-04
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公开(公告)号： US09550997B2公开(公告)日： 2017-01-24
- 发明人: Jung-Hoon Sohn , Jung-Hoon Bae , Hyun-Jin Kim , Kwang-Mook Lim
- 申请人： Jung-Hoon Sohn , Jung-Hoon Bae , Hyun-Jin Kim , Kwang-Mook Lim
- 申请人地址： KR Daejeon
- 专利权人： Korean Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korean Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12P21/02 ; C12N15/62
摘要：
The present invention relates techniques for identifying suitable secretion fusion partner (SFP) for hyper-secretory production of recombinant proteins. The SFPs can be obtained from secretome analyzes. Recombinant proteins are produced in a fusion form with a secretion fusion partner (SFP) and can be separated from the SFP by in vitro protease treatment. SFPs of this invention greatly improve the secretion level of target proteins and peptides which are valuable for bio-pharmaceuticals and the bio-industry.