The described embodiments include a main memory and a cache memory (or “cache”) with a cache controller that includes a mode-setting mechanism. In some embodiments, the mode-setting mechanism is configured to dynamically determine an access pattern for the main memory. Based on the determined access pattern, the mode-setting mechanism configures at least one region of the main memory in a write-back mode and configures other regions of the main memory in a write-through mode. In these embodiments, when performing a write operation in the cache memory, the cache controller determines whether a region in the main memory where the cache block is from is configured in the write-back mode or the write-through mode and then performs a corresponding write operation in the cache memory.