An interface seal for an electrical connector assembly that includes a housing and a seal retainer defining a seal recess and configured to couple to the housing, is disclosed. The interface seal includes a main body portion configured to substantially surround the housing to create a sealing interface, and an anti-rotation projection coupled to and extending from the main body portion. The anti-rotation projection includes (i) an engagement portion extending in a first direction and (ii) a connecting portion that couples the engagement portion with the main body portion and that extends in a second direction different from the first direction. The anti-rotation projection cooperates with the seal recess to inhibit movement of the interface seal with respect to the housing and seal retainer.