A system and method for calibrating an optical module. The optical module including a microprocessor with non-volatile memory is provided at a calibration station for measuring calibrated value of a device parameter against raw values starting from minimum value in each of multiple zones of a primary parameter with one or more secondary parameters at least being set to a basis calibration point to determine coefficients for generating a N-spline function for the multiple zones and multiple multipliers for each zone corresponding to multiple calibration points. The coefficients and multiple multipliers are stored in the non-volatile memory and reused respectively for calculating a basis calibrated value based on any current raw value of the primary parameter a N-spline function in particular zone and for determining a final multiplier by interpolation of the multiple multipliers associated with the one or more secondary parameters, leading to a calibrated value for any condition.