Invention Grant
- Patent Title: Heterocycle-substituted tetracyclic compounds and methods of use thereof for the treatment of viral diseases
- Patent Title (中): 杂环取代的四环化合物及其用于治疗病毒性疾病的方法
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Application No.: US14761256Application Date: 2013-12-31
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Publication No.: US09555038B2Publication Date: 2017-01-31
- Inventor: Wensheng Yu , Ling Tong , Joseph A. Kozlowski , Oleg Selyutin , Lei Chen , Jae-Hun Kim , Deyou Sha , Razia Rizvi , Bandarpalle Shankar
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Jeffrey P. Bergman; Catherine D. Fitch
- Priority: WOPCT/CN2013/000038 20130116
- International Application: PCT/CN2013/001676 WO 20131231
- International Announcement: WO2014/110705 WO 20140724
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D513/04 ; A61K31/5365 ; A61K45/06 ; A61K31/4985 ; A61K31/7056 ; A61K31/7072
Abstract:
The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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