Invention Grant
US09556141B2 Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof
有权
制备N-取代的1H-吡唑-5-羧酸酯化合物及其衍生物的方法
- Patent Title: Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof
- Patent Title (中): 制备N-取代的1H-吡唑-5-羧酸酯化合物及其衍生物的方法
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Application No.: US14359446Application Date: 2012-11-20
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Publication No.: US09556141B2Publication Date: 2017-01-31
- Inventor: Maximilian Dochnahl , Karsten Koerber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frassetto , Gemma Veitch
- Applicant: BASF SE
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Brinks Gilson & Lione
- Priority: EP11189973 20111121
- International Application: PCT/EP2012/073128 WO 20121120
- International Announcement: WO2013/076092 WO 20130530
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D471/10 ; C07D401/04
Abstract:
The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carboxylate compound of the formula (I-A) comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined in the description and the claims, with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a carbonylation by reacting it with a reagent selected from the group consisting carbon dioxide or a carbon dioxide equivalent, to obtain a compound of formula (I-A); and it relates to further conversions to yield a N-substituted 1H-pyrazole-5-carbonyl chloride compound of the formula (I)
Public/Granted literature
- US20150087843A1 Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof Public/Granted day:2015-03-26
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