Invention Grant
- Patent Title: TFPI inhibitors and methods of use
- Patent Title (中): TFPI抑制剂和使用方法
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Application No.: US14677581Application Date: 2015-04-02
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Publication No.: US09556230B2Publication Date: 2017-01-31
- Inventor: Michael Dockal , Rudolf Hartmann , Markus Fries , Friedrich Scheiflinger , Hartmut Ehrlich , Ulrich Reineke , Frank Osterkamp , Thomas Polakowski
- Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
- Applicant Address: CH US IL Bannockburn
- Assignee: BAXALTA GMBH,BAXALTA INCORPORATED
- Current Assignee: BAXALTA GMBH,BAXALTA INCORPORATED
- Current Assignee Address: CH US IL Bannockburn
- Agency: Troutman Sanders LLP
- Main IPC: A61K38/57
- IPC: A61K38/57 ; C07K14/745 ; C07K7/08 ; C07K14/81 ; G01N33/68 ; G06F19/16 ; A61K38/00
Abstract:
The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
Public/Granted literature
- US20150232514A1 TFPI INHIBITORS AND METHODS OF USE Public/Granted day:2015-08-20
Information query
IPC分类:
