Invention Grant
- Patent Title: Preparation of and formulation comprising a MEK inhibitor
- Patent Title (中): 包含MEK抑制剂的制剂和制剂
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Application No.: US14974655Application Date: 2015-12-18
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Publication No.: US09562016B2Publication Date: 2017-02-07
- Inventor: Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
- Applicant: Novartis AG , Array BioPharma, Inc.
- Applicant Address: US CO Boulder CH Basel
- Assignee: Array BioPharma, Inc.,Novartis AG
- Current Assignee: Array BioPharma, Inc.,Novartis AG
- Current Assignee Address: US CO Boulder CH Basel
- Agency: Fish & Richardson P.C.
- Main IPC: C07D235/06
- IPC: C07D235/06 ; A61K47/02 ; A61K47/12 ; A61K47/26 ; A61K47/38 ; A61K9/20 ; C30B7/08 ; C30B29/54 ; C07D235/08
Abstract:
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Public/Granted literature
- US20160168103A1 PREPARATION OF AND FORMULATION COMPRISING A MEK INHIBITOR Public/Granted day:2016-06-16
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