Various embodiments relating to executing different types of instruction code in a micro-processing system are provided. In one embodiment, a micro-processing system includes a memory/storage subsystem configured to store non-native instruction set architecture (ISA) code and native ISA code in a common address space, fetch logic configured to retrieve the non-native ISA code and native ISA code from the common address space, instruction type determining logic configured to determine, at runtime, whether fetched instruction code is non-native ISA code or native ISA code, and processing logic configured to execute the fetched instruction code via a first pipeline configuration in response to the instruction type determining logic determining that the fetched instruction code is non-native ISA code, and via a second pipeline configuration which is different than the first pipeline configuration, in response to the instruction type determining logic determining that the fetched instruction code is native ISA code.