A method of medical image registration includes obtaining a first medical image generated before a medical surgery; obtaining a second medical image generated in real time during the medical surgery; extracting landmark points of at least two adjacent anatomical objects recognizable in the second medical image among a plurality of anatomical objects near an organ of interest of a patient from the first medical image and the second medical image; and registering the first medical image and the second medical image based on a geometrical correlation among the adjacent anatomical objects indicated by the landmark points of the first medical image and a geometrical correlation among the adjacent anatomical objects indicated by the landmark points of the second medical image.