A single probe percutaneous surgical instrument for de-bulking/removing thrombus/clog/calculi has an actuator assembly (4), a probe set (13), an operating switch (10), and a generator (12). The actuator assembly (4) has a proximal end (4a) and a distal end (4b), a cable connector (1), a suction connector (2), and actuator switch (3) mounted with the proximal end (4a) and a horn (5) mounted at the distal end (4b). The probe set (13) is mounted to the horn (5) and includes at least one disturber (6), a spring (7), a 10 spring adjusting nut (8) and a fixed probe (9), the cable connector (1) connecting to the generator (12) through a cable, and the suction connector (2) connecting to a suction system. The actuator switch (3) controls a probe vibration mode through the generator (12), the actuator assembly (4) comprising at least two piezoelectric ceramic rings (18) assembled with a bolt (15), the horn (5) and a back plated (16). The horn (5) is mounted on the distal end (4b) of the actuator assembly (4), the horn (5) being coupled with the bolt (15) and the piezoelectric rings (18), the at least one disturber (6) and the spring (7) being mounted on the fixed probe (9) using the spring adjusting nut (8). The generator (12) includes a microprocessor and the microprocessor is programmed to control the actuator vibration mode, the fixed probe optimal vibration frequency and the disturbing strength of the disturbers.